Understanding HTLV-I Protease

ABBOTT PRISM HTLV-I/HTLV-II Package Insert

The Impact of Immune Response on HTLV-I in HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)

    Human T lymphotropic virus type I (HTLV-I) is a retrovirus which is associated with adult T cells leukaemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in a minority of HTLV-I-infected individuals. It is not clear why a minority of HTLV-I-infected individuals develop HAM/TSP and majority remains lifelong carriers. It seems that the interaction between the v...

Roles of HTLV-I p19 and natural antibody to HTLV-I in host immune responses.

Since the discovery of human T cell leukemia/lymphoma virus type I (H1LV-I) [5], the immune status of H1L V-I-infected hosts, including patients with adult T cell leukemia (ATL) , has not yet been sufficiently investigated [2-4]. As the first step in this kind of study, we have studied the nonspecific activity of peripheral mononuclear cells (PMNC) from A1L patients and seropositive H1L V-I car...

Detection of anti-HTLV-I Tax antibodies in HTLV-I enzyme-linked immunosorbent assay-negative individuals.

The HTLV-I tax gene protein (Tax) is not packaged within the mature viral particle from which the proteins for the commercially available enzyme-linked immunosorbent assay (ELISA) are derived. Screening of 162 individuals within a cohort of white intravenous (IV) drug abusers, previously identified as having an increased incidence of HTLV-I infection, demonstrated that seven of them had antibod...

Cutaneous Manifestations in HTLV-I Positive Blood Donors